Topic

lead poisoning

Title

Lead Encephalopathy in an Infant Mimicking a Neurometabolic Disorder.

Conclusion

Lead poisoning should be considered in the differential diagnosis of infants with regression of milestones.

Authors

Sahu JK, Sharma S, Kamate M, Kumar A, Gulati S, Kabra M, Kalra V

Citation

J Child Neurol. 2009 Jul 25.

Context


New Delhi, India

Abstract


We report the case of a 7-month-old child who presented with regression of milestones, seizures, altered sensorium, and vomiting. An elder sibling had died of similar complaints. Lead encephalopathy was considered because of presence of microcytic hypochromic anemia and dense metaphyseal bands on wrist radiogram. Magnetic resonance imaging (MRI) of the brain revealed diffuse dysmyelination involving both periventricular and subcortical white matter. Such diffuse changes have not been described previously. The child's father was operating an illicit leadacid battery manufacturing unit at home. The child was subjected to chelation therapy, which was accompanied by environmental exposure source modification. He showed significant improvement. Our case highlights the importance of taking a detailed occupational history and considering lead poisoning in the differential diagnosis of encephalopathy of unidentifiable cause.

Policy Implications

Home lead battery manufacturing is dangerous and not regulated.

Web link

jcn.sagepub.com/cgi/rapidpdf/0883073809338625v1


Keywords

lead, encephalopathy